The difference between purified water equipment and injection water equipment.
Categories: Industry Blog
Release time:2024-11-13
What is the difference between purified water equipment and injection water equipment?
Purified water: The electrolytes in the water are almost removed, and the colloidal substances, microbial particles, dissolved gases, organic matter, etc., that are not soluble in water have also been removed to a very low level. Purified water is water suitable for medicinal use, obtained from raw water that meets drinking water standards through distillation, ion exchange, reverse osmosis, or other suitable methods, and contains no additives. It can be used as a solvent for preparing ordinary pharmaceutical formulations or as experimental water, but it must not be used for the preparation of injections. Generally, the residual salt content in purified water should be controlled to below 0.1 mg/L, and at a water temperature of 25°C, its conductivity should be below 5.1 μs/cm.
Water for injection: The purity of the water is similar to that of purified water, with the main difference being that it does not contain microorganisms and pyrogenic substances, and is obtained from purified water through distillation. It is required to monitor each preparation step at all times and regularly clean and disinfect the equipment for the preparation and delivery of water for injection. Generally, it should be stored above 80°C, maintained in a circulation state above 65°C, or stored in a sterile state below 4°C, and used within 12 hours of preparation. The "Chinese Pharmacopoeia" stipulates that water for injection is water obtained from purified water through distillation; it should meet the requirements of bacterial pyrogen tests; and water for injection must be produced, stored, and distributed under conditions that prevent the generation of pyrogens.
Although purified water and water for injection are both commonly used water qualities in the pharmaceutical industry, there are essential differences. The fundamental difference lies in the quality of the raw water used and the preparation processes. Below are specific related knowledge points organized by Xiao Li from Chuanglian Purification regarding purified water equipment and injection water equipment for reference:
First, let's talk about the quality of the raw water. Purified water uses water sources that meet drinking water standards as raw water, while water for injection uses purified water that meets standards as raw water. There is a significant difference in the source of raw water between the two. Additionally, the preparation processes differ; there are many methods for preparing purified water, as long as the quality of the output water meets the standards for purified water. However, water for injection has certain restrictions; in China, the production process for water for injection must be distillation.
Keywords: The difference between purified water equipment and injection water equipment.
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